To get to Akinada Tobishima Kaido, leave Hiroshima area via Hiroshima Kure Road (Kurea line). Get on Sanyo Expressway and cross Kyushu, Kansai and Sanin regions. At Takaya Junction get on Higashi-Hiroshima Kure Expressway. Once you reached Takehara area, get on the national highway 185, which is known as Sazanami Kaido. You can also come via Shikoku region (Imabari, Ehime Prefecture) by leading to Setouchi Shimanami Kaido. Once you get in Imabari (Ehime Prefecture), the ferry.
(*If you use public transportation, ask all JR and buss companies)